I saved my game then I left my computer alone for 2 weeks. I come back to play my save but it is nowhere to be found! I renamed all of the .sims3.backup files in my saves folder to .sims3 and loaded my game, my save is still nowhere to be found. I checked my recycle bin for .sims3 files, and there seems to be nothing in there. I am rather worried about losing my sims in the save (I like to make a base in Create-a-Household then enable some master controller features in-game and finish the sim.) Is there any way I can restore the sims in the save or just the save in general without the .sims3 or .sims3.backup file?

Just to be clear, what you're looking for are folders with names ending in .sims3. There are no files with that name.
The files in each folder should be:
1a5tf1l3.dat
Meta.data
[worldname]_0x00000000.nhd
[worldname]_0x00000000ExportDB.package
TravelDB.package (if you have World Adventures and have traveled to a foreign location)
+ more .nhd and ExportDB files if you've traveled.

The bolded ones are basic and necessary to open your save game. Do you have those?

I remember reading somewhere here that Windows 10 mistakenly backs up the My Documents folder to the cloud and interferes with TS3? I'm not sure but it's worth a shot if you have Win10. It would also explain your savegames disappearing.

P.S. I know this is like the easiest thing and should have written it first, but have you given your save a name with weird characters? Try renaming the folder to just "savegame.sims3" and see if the game reads it.

I don't have any of the files, as I don't have the save folder. The save does not have any special characters. I will try to reverse any changes that Windows 10 may have made to the folders.

Have you checked your One Drive?

Nope. I don't use One Drive, nor did I think to back up the save when there was already a backup in the saves folder.

win.10 uses one drive. If you didn't disable it ,your saves could be there!

Nothing involving Sims is in there.

Sorry to hear that! I would suggest to look in every folder in your documents,including the sims folders,if you by mistake placed your saves folder in one of them.Wish you luck.