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It's not about the amount, but the quality of what you have installed. It seems you installed broken custom content OR it could be that you install a mod that doesn't match your patch level OR the mod requires something you don't have installed. For example, I remember than NRaas' Cupcake would crash your game IF you don't have the required Store set (bakery) installed.
I recommend that you remove ALL your CC and start the
50% method of installation.