My WorldCaches are through the roof. I just don't want to delete something that won't come back once the game restarts. What will it do? Is it safe?
This may actually be a dumb question, but I don't see anything about it anywhere so.. Please Help!

I'm not sure. But personally I deleted worldcaches folder since installing the mods and my game ran very ok.
Now in my Electronic Arts folder, no worldchaches and everything's fine.

I dunno why but my game is fine.

Have a look here. It's related to game crashes but there's information about the deletion of caches to answer your question