Sims 3 hands down-whenever my sims have babies they're either black (and I mean literally BLACK, not ethnically black) or I get this flesh coloured line coming out of the baby's head. It's really irritating.

I played that for a little bit, too. My character/avatar kept turning back into a man, and I'm fairly certain a customer got stuck sitting once. At least I think it was Cafe World. It's hard to keep track of all those dang games...

I'm putting Sherlock Holmes on this list simply because they forgot to include the walking animation for Watson, so he stalks you the entire game.

Haaaa I saw a video of the creepy Watson here
Thats one of those things that I wouldn't want to fix just for pure quirkiness and amusement, just like the giant's launching you into space on Skyrim!

I'll say fallout. Never had a session without problems on the Xbox or the PC.

Hmm.

Cafe World is terrible.
TS3 is filled with glitches (but I am running it on a system that sucks, so....)

I'd have to say Saint's Row The Third. I'll be driving down the street and see numerous vehicles with people standing on top of the car. People get stuck in windows and buildings and you only see their hands or heads. I blow up a rival gangs' car and pieces of the wreckage attach to me, even if I get into another car.

Funny stuff.

The Sims 3...on a crappy computer. Sims 3 on a good computer + Sims 3 fully updated = A pretty decent game.

...The Sims 2 on a Windows 7

Two Worlds. Was not a good start from Reality Pump. Most disturbing was the dialogue that looked like it was skipping all the time.
The Witcher was from the start also pretty glitched and actually it was half finished. Huge fps drops and sometimes black screens. CdProjekt Red did fix this with patch 1.3 and with the EE the game was more polished.
Sacred 2 had also it's quirks, until ascaron came with patch 2.34, which solved problems like random CTD's. However, with ice & blood new problems were introduced and since ascaron is no more and deep silver doesn't care they weren't solved. A community patch solve the new problems.